CCL25 increases thymopoiesis after androgen withdrawal

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IMMUNOBIOLOGY CCL25 increases thymopoiesis after androgen withdrawal

Although studies have demonstrated that androgen withdrawal increases thymic size, molecular mechanisms underlying this expansion remain largely unknown. We show that decreased androgen signaling leads to enhanced immigration of bone marrow T-cell precursors, as manifested by both an early increase of early thymic progenitors (ETP) and improved uptake of adoptively transferred quantified precur...

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ژورنال

عنوان ژورنال: Blood

سال: 2008

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood-2008-04-153627